I would revisit the balance of power, in hopes of keeping the Executive branch in check. The current officeholder at the top, and those around him, are always looking for loopholes, benefitting from a predatory reading of things and making a shambles of the role of Congress– basically ignoring laws whose intent has always been to maintain a certain order and keep the fabric of society from fraying to the point of chaos and anarchy.
A close second would be a crusade for changing the current tax structure to be more equitable across income levels– since federal funding has always mattered when it comes to programs focused on infrastructure and health maintenance and improvement, along with research grants and a spectrum of societal needs that benefit from a dependable and consistent financial shot in the arm.
3 Cents' 
This really captures how some things are meant to stay whole and not be tested just for the sake of it.
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